Season 21

E1. Johnny Knoxville; Olivia Cooke; BLACKPINK

Sep 19, 2022 · 41m

Jimmy welcomes guests Johnny Knoxville and Olivia Cooke. Musical performance by BLACKPINK.

E2. Kathy Griffin; Chad Kroeger and JT Parr; Madison Cunningham

Sep 20, 2022 · 41m

Jimmy welcomes guests Kathy Griffin, and Chad Kroeger and JT Parr. Musical performance by Madison Cunningham.

E3. John Boyega; Tyler James Williams; Weezer

Sep 21, 2022 · 42m

Jimmy welcomes guests John Boyega and Tyler James Williams. Musical performance by Weezer

E4. Allison Janney; Chris Estrada; Frankie Quiñones; Yung Gravy

Sep 22, 2022 · 41m

Jimmy welcomes guests Allison Janney, Chris Estrada, and Frankie Quiñones. Musical performance by Yung Gravy.

E5. Amy Schumer, Charlamagne Tha God, Run the Jewels

Sep 26, 2022 · 41m

Jimmy welcomes comic Amy Schumer, TV host Charlamagne Tha God, and a musical performance by Run the Jewels.

E6. David Letterman, Tracy Morgan

Sep 27, 2022 · 41m

Jimmy welcomes TV host David Letterman and actor Tracy Morgan.

E7. Mila Kunis, Ramy Youssef, Future

Sep 28, 2022 · 41m

Jimmy welcomes actress Mila Kunis, actor Ramy Youssef, and a musical performance by Future.

E8. Ben Stiller, Desus Nice, Yeah Yeah Yeahs

Sep 29, 2022 · 41m

Jimmy welcomes producer Ben Stiller, TV personality Desus Nice, and a musical performance by Yeah Yeah Yeahs.

E9. Jason Bateman, Action Bronson

Sep 30, 2022 · 41m

Jimmy welcomes actor Jason Bateman and a musical performance by Action Bronson.

E10. Charlie Hunnam, Iliza Shlesinger, NAV, Don Toliver

Oct 3, 2022 · 41m

Charlie Hunnam ("Shantaram"), Iliza Shlesinger ("All Things Aside"), Musical Guests NAV feat. Don Toliver

E11. Norman Reedus, Danielle Deadwyler, Miranda Lambert

Oct 4, 2022 · 41m

Jimmy welcomes actor Norman Reedus, actress Danielle Deadwyler, and a musical performance by Miranda Lambert.

E12. Keanu Reeves, Judd Apatow, Phoenix

Oct 5, 2022 · 41m

Keanu Reeves ("BRZRKR: Vol. 2"), Judd Apatow ("Bros"), Musical Guests Phoenix

E13. David Spade, FLO, Mookie Betts

Oct 6, 2022 · 41m

Actor David Spade (podcast series, "Fly on the Wall with Dana Carvey and David Spade"); professional baseball player Mookie Betts (documentary "Jackie Robinson: Get to the Bag", Los Angeles Dodgers); Flo performs.

E14. Magic Johnson, Fortune Feimster, Wet Leg

Oct 10, 2022 · 41m

Former professional basketball player Magic Johnson; comic Fortune Feimster; Wet Leg performs.

E15. Jamie Lee Curtis, Lucas Bravo, Midland, Jon Pardi

Oct 11, 2022 · 41m

Actress Jamie Lee Curtis; actor Lucas Bravo; Midland and Jon Pardi perform.

E16. Jessica Chastain, Maren Morris

Oct 12, 2022 · 41m

Actress Jessica Chastain; Maren Morris talks and performs.

E17. George Clooney, Julia Roberts, Omar Apollo

Oct 13, 2022 · 41m

Actors George Clooney and Julia Roberts ("Ticket to Paradise"); Omar Apollo performs.

E18. Josh Gad, Pamela Adlon, Ariel Elias

Oct 24, 2022 · 41m

Actor Josh Gad; actress Pamela Adlon; comic Ariel Elias.

E19. Charlize Theron, Lewis Hamilton, Armani White

Oct 25, 2022 · 41m

Actress Charlize Theron; race car driver Lewis Hamilton; Armani White performs.

E20. Lupita Nyong'o, Danai Gurira, Letitia Wright, Duran Duran

Oct 26, 2022 · 41m

Actresses Lupita Nyong'o, Danai Gurira and Letitia Wright ("Black Panther: Wakanda Forever"); Duran Duran performs.

E21. Quentin Tarantino, Tenoch Huerta, Edgar Winter

Oct 27, 2022 · 41m

Filmmaker Quentin Tarantino; actor Tenoch Huerta; Edgar Winter sits in with Cleto and the Cletones.

E22. Gwyneth Paltrow, Patton Oswalt

Oct 31, 2022 · 41m

Actress Gwyneth Paltrow; comic Patton Oswalt.

E23. Mindy Kaling, Frank Grillo, Goose

Nov 1, 2022 · 41m

Actress Mindy Kaling; actor Frank Grillo; Goose performs.

E24. Nick Kroll, Yvonne Strahovski, Viagra Boys

Nov 2, 2022 · 41m

Nick Kroll, Yvonne Strahovski, Viagra Boys

E25. Rob McElhenney, Emayatzy Corinealdi

Nov 3, 2022 · 41m

Rob McElhenney, Emayatzy Corinealdi

E26. Dana Carvey, Jonathan Majors

Nov 7, 2022 · 41m

Dana Carvey, Jonathan Majors, SoFaygo

E27. Bill Maher, George Conway

Nov 8, 2022 · 41m

Bill Maher, George Conway, Breland

E28. Jason Momoa, Luke Grimes

Nov 9, 2022 · 41m

Jason Momoa, Luke Grimes, Lainey Wilson

E29. Brian Tyree Henry, Lizzy Caplan

Nov 10, 2022 · 41m

Brian Tyree Henry, Lizzy Caplan

E30. Chris Hemsworth, Meghann Fahy

Nov 14, 2022 · 41m

Chris Hemsworth, Meghann Fahy, Maneskin