Tobey Maguire

Spider-Man / Peter Parker

Willem Dafoe

Green Goblin / Norman Osborn

Kirsten Dunst

Mary Jane Watson

James Franco

Harry Osborn

Cliff Robertson

Ben Parker

Rosemary Harris

May Parker

J.K. Simmons

J. Jonah Jameson

Joe Manganiello

Flash Thompson

Gerry Becker

Maximilian Fargas

Bill Nunn

Joseph 'Robbie' Robertson

Jack Betts

Henry Balkan

Stanley Anderson

General Slocum

Ron Perkins

Dr. Mendel Stromm

Michael Papajohn

Carjacker

K.K. Dodds

Simkins

Ted Raimi

Hoffman

Bruce Campbell

Ring Announcer

Elizabeth Banks

Miss Brant

John Paxton

Houseman

Tim DeZarn

Philip Watson

Taylor Gilbert

Madeline Watson

Randy Poffo

Bone Saw McGraw

Larry Joshua

Wrestling Promoter

Timothy Patrick Quill

Wrestling Arena Guard

Lisa Danielle

Bone-ette